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KMID : 1123920090230020480
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 2 p.480 ~ p.487
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Seed of Trichosanthes kirilowii MAXIM Inhibits TNF--induced Migration In Human Aortic Smooth Muscle Cells Via MMP-9 Inhibition
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Kim Jae-Eun
Choi Dall-Yeong
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Abstract
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Atherosclerosis, slow progressing inflammatory lesion in arteries, is one of the major causes of cardiovascular diseases. As mortality due to cardiovascular disease keeps increasing in Korea, researches on pathological mechanism of atherosclerosis may be beneficial in fighting against cardiovascular diseases. It is known that migration and MMP-9 secretion of Vascular Smooth Muscle Cell(VSMC) play a significant part in pathogenesis of atherosclerosis, although detailed mechanism of entire process is not clarified. We investigated whether the seeds of Trichosanthes kirilowii maxim (TS), inhibit migration and MMP-9 production of HASMC(human aortic SMC), which were induced by TNF-${\alpha}$ treatment. Migration assay showed that TS inhibited the migration of HASMC induced by TNF-${\alpha}$, in dose dependent manner. Also by Zymography MMP-9 production of HASMC was found to be reduced by TS, both in time and in dose dependent manner. Western blotting results suggest TS suppress activity of MAPkinases.
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KEYWORD
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Trichosanthes seed(TS), anti-atherosclerotic, MMP-9, migration, HASMC, MAPKinase
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